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Copper (II) bromide/NMO system for α-amination of esters in solvent-free condition

28 March 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Copper (II) bromide/ N-methylmorpholine N-oxide promoted α-amination of esters in solvent-free condition is reported. The α-amino esters are precursors for α-amino acids. This method provides α-amino esters in 58-83% yields. The polar solvent dimethyl sulfoxide was avoided and the reactions were performed in solvent-free condition. NMO successfully oxidizes Cu(I)Br to regenerate the Cu(II)Br catalyst. The isolated CuBr2 catalyst was recycled twice.

Keywords

Copper (II) bromide • NMO • ester • amination • innovation

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Version History

Mar 28, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-s8ft1
D O I: 10.26434/chemrxiv-2023-s8ft1 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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