Organotitanium Click Chemistry

The click chemistry of titanium exemplified by the “green” [3+2] cycloaddition of the [Ti-N3] moiety with nitriles RCN to form a tetrazole ligand, is currently limited in scope, but the future of this open and wide field is bright, full of promising new synthetic approaches discussed herein, for pharmacological and bio orthogonal applications. This prediction is based on emerging click reaction possibilities of existing titanium azides, from the commercially available Ti(N3)4, Cp2Ti(N3)2 (iPrO)2Ti(N3)2, and their multiple derivatives, participating in cycloaddition, exchange and other reaction types with alkynes, alkenes, nitriles, and related click synthons. Structural, mechanistic, stereo control and other effects on reactivity will be briefly discussed. The main emphasis in this review article is on recently discovered organotitanium complexes like 2-phenylindole titanium dichloride, serving as springboards of a new era in organotitanium click chemistry, by the original syntheses of potentially bioactive complexes.