Photoredox-catalysed Hydroaminoalkylation of on-DNA N- Arylamines

27 October 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient approach to the photoredox-catalysed hydroaminoalkylation between on-DNA secondary N-substituted (hetero)arylamines and vinylarenes has been developed and explored. The methodology was examined with a broad scope of vinylarenes and secondary arylamines to establish a preferred building block profile for the process. Compatible substrates furnished the desired derivitised amine products in modest to excellent yields and with minimial or no detectable by-products.

Keywords

DNA-encoded library
photoredox
hydroaminoalkylation
DNA-compatible chemistry

Supplementary materials

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Supplementary Information
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synthetic methods, molecular characterisation, supporting data
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