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Polyethylene glycol-b-polylactic acid polymersome elongation through osmotic pressure mediated membrane tension and fusion

05 October 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Polyethylene glycol-b-polylactic acid (PEGPLA) polymersomes elongate under osmotic pressure. Hypertonic NaCl solutions statistically increased the zeta potential from negative to neutral. Change in charge and PLA hydrophilicity allow for binding of polymersomes depots to increase membrane surface area. PEGPLA polymersomes exhibit biomimicry in their homeostatic responses to increased osmotic pressure.

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Version History

Oct 05, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-2c8c2
D O I: 10.26434/chemrxiv-2022-2c8c2 [opens in a new tab]

Funding

National Institutes of Health
P20GM103499-20

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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