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Ni-catalyzed Regioselective Reductive 1,3-Dialkenylation of Alkenes

28 September 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Dicarbofunctionalization is an important efficient synthetic technique for adding two chemical moieties across an alkene. Here, a novel method of reductive dicarbofunctionalization has been developed using a single alkenyl triflate as the electrophile, combined with an unactivated alkene. The reaction does not require an external auxiliary and proceeds with complete regioselectivity.

Keywords

Nickel
dialkenylation
alkene
dicarbofunctionalization

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Version History

Sep 28, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-8jrzc
D O I: 10.26434/chemrxiv-2022-8jrzc [opens in a new tab]

Funding

NIH NIGMS
R35GM133438

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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