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Abstract
An open-air method for the transition metal-free direct amination of nitro(hetero)arenes by anilines is disclosed. In this methodology, an aromatic C-H bond is substituted via oxidative nucleophilic aromatic substitution of hydrogen (ONSH). DFT calculations and mechanistic studies support a dianion pathway with oxidation by molecular oxygen as the rate-limiting step.
Supplementary materials
Title
ESI: Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen
Description
Supporting information
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