A long-wavelength xanthene dye for photoacoustic imaging

18 July 2022, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Photoacoustic (PA) imaging is a powerful biomedical imaging modality. We designed KeTMR and KeJuR, two xanthene-based dyes that readily obtained through a 2-step synthetic route. KeJuR has low molecular weight, good aqueous solubility, and superior chemical stability compared to KeTMR. KeJuR shows robust PA signal at 860 nm excitation and can be paired with traditional PA dyes for multiplex imaging in blood samples under tissue-mimicking environment.

Keywords

fluorophores
photoacoustic
long-wavelength
synthesis

Supplementary materials

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Electronic Supporting Information
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Methods, Synthesis, and Supporting Figures
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