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Abstract
A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centres on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation.
Supplementary materials
Title
Supporting Information: Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
Description
Contains full experimental procedures and spectroscopic characterisation for all reactions and synthesis of Meldrum’s acid derivatives, and copies of the 1H and 13C NMR spectra of final products.
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