Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Fluoro-bicyclo[1.1.1]pentanes

29 April 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

After more than 20 years of trials, a practical scalable approach to fluoro-bicyclo[1.1.1]pentanes (19F-BCPs) has been developed. Physico-chemical properties of fluoro-bicyclo[1.1.1]pentanes have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen instead of the fluorophenyl ring.

Keywords

bicyclo[1.1.1]pentane
fluorine
BCP
bioisostere
medicinal chemistry

Supplementary materials

Title
Description
Actions
Title
Supporting Information
Description
SI
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Apr 29, 2022 Version 1

Metrics

3,453
1,972
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-8b85l
D O I: 10.26434/chemrxiv-2022-8b85l [opens in a new tab]

Funding

European Research Council
101000893 - BENOVELTY

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share