Carbohydrate-DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates

Hongxin Zeng; Yanjing Li; Yang Zhang; Shi-Yang Xu; Yingwei Wang; Dawen Niu

doi:10.26434/chemrxiv-2023-z0mqc

Organic Chemistry

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Carbohydrate-DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates

08 March 2023, Version 1

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Abstract

Herein, we report a method that enables the synthesis of carbohydrate-DNA conjugates by radical addition, in which the gen-eration of glycosyl radicals from readily available and bench-stable unprotected glycosyl sulfinates is the key. These reactions were carried out under mild conditions and tolerate a broad substrate scope.

Keywords

Carbohydrates

DNA-encoded libraries

Photochemistry

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