Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Protein corona alters the mechanisms of interaction between silica nanoparticles and lipid vesicles

08 April 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We investigate the impact of a bovine serum albumin corona on interactions between silica nanoparticles (SNPs) of two different sizes and giant lipid vesicles. The protein corona alters the morphological response of vesicles to SNPs, demonstrating that a protein corona can change the interaction mechanism between nanoparticles and lipid membranes.

Keywords

Giant Unilamellar Vesicles
Bovine serum albumin
Confocal microscopy
Nanoparticle-membrane interactions
Vesicle morphology
Protein corona

Supplementary materials

Title
Description
Actions
Title
Supplementary information - methods and supporting data
Description
Detailed methods. TEM characterisation of the nanoparticles. DLS and zeta potential characterisation of the nanoparticles. BSA-only control experiment with GUVs.
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Apr 08, 2022 Version 1

Metrics

533
154
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-2xwnv
D O I: 10.26434/chemrxiv-2022-2xwnv [opens in a new tab]

Funding

University of Leeds

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share