Reagent Free Light-Driven Site Selective Carbon-Carbon Coupling of Aliphatic Alcohols with 1,4-Naphthoquinones

Here, first-ever an -selective Csp3‒H bond functionalization of primary aliphatic alcohols with 1,4-naphthoquinones yield-ed Csp2‒Csp2 coupled products is reported, driven by blue-LEDs light in photo-catalyst, metal, base, reagent free conditions. In this transformation, cleavage of three C-H bonds (two sp3-C-H, one sp2-C-H, and one O-H) and four new bonds formed, leading to fluorescent 2-acylated-1,4-naphthohydroquinones.