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Based-Catalyzed Stereoselective Thiosulfonylation of Ynones

22 February 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The first catalytic vicinal thiosulfonylation of ynones has been developed. Under the catalysis of 1-10 mol% Cs2CO3, various thiosulfonates underwent Michael addition/nucleophilic substitution tandem reaction with different ynones to form C-SO2 and C-S bonds simultaneously and produce multifunctional vinyl sulfones in high yields and excellent E-selectivity.

Keywords

thiosulfonylation
ynones
thiosulfonates
tandem reaction
vinyl sulfones

Supplementary materials

Title
Description
Actions
Title
Supporting Information for Based-catalyzed Stereoselective thio sulfonylation of Ynones
Description
Includes general information, general procedure for the synthesis of vinylsulfones, characterization of all products, and copies of NMR spectra.
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Version History

Feb 22, 2022 Version 1

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License

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-qsjzm
D O I: 10.26434/chemrxiv-2022-qsjzm [opens in a new tab]

Funding

National Natural Science Foundation of China
21662029

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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