Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Visible-Light Driven Enantioselective Radical Addition to Imines Ena-bled by Excitation of Chiral Phosphoric Acid–Imine Complex

14 February 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A visible-light driven enantioselective radical addition to imines enabled by the direct excitation of a chiral phosphoric acid-imine complex was developed. By using benzothiazolines as the radical precursors, chiral amine products were obtained with high enantioselectivities (up to 98% ee). Mechanistic studies elucidated that the chiral phosphoric acid-imine complex has photoredox activities for oxidizing benzothiazolines.

Keywords

enantioselective reaction
photoreaction
chiral phosphoric acid
radical addition

Supplementary materials

Title
Description
Actions
Title
Supporting Information
Description
Additional experimental details and characterization data for new compounds
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Feb 14, 2022 Version 1

Metrics

1,146
857
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-606dn
D O I: 10.26434/chemrxiv-2022-606dn [opens in a new tab]

Funding

JSPS KAKENHI
JP20H00380
JSPS KAKENHI
JP20H04826
JSPS KAKENHI
JP20K15287

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share