An Inverse Thermogelling Bioink Based on an ABA Type Poly(2-Oxazoline) Amphiphile

Hydrogels are key components in several biomedical research areas such as biofabrication. Here, a novel ABA-type triblock copolymer is introduced that undergoes a inverse thermogelation, i.e. it forms a hydrogel about cooling aqueous polymer solutions. The macroporous hydrogel was rheologically investigate in detail and used for 3D printing using an extrusion based printer. Preliminary experiment show very good cytocompatibility of NIH 3T3 cells also after printing and the possibility to combine the novel material with other hydrogel forming materials such as alginate.