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(2-Fluoroallyl)pyridinium Tetrafluoroborates: Novel Fluorinated Electrophiles for Pd-Catalyzed Allylic Substitution

24 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient two-step approach to 2-fluoroallyl amines was developed that involves the synthesis of (2-fluoroallyl)pyridinium tetrafluoroborates from readily available gem-bromofluorocyclopropanes and the application of the former as novel and stable 2-fluoroallyl electrophiles for Pd-catalyzed allylic substitution

Keywords

fluoroalkenes
fluorocyclopropanes
palladium allylic substitution

Supplementary materials

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Description
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ESI - Experimental procedures
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ESI-NMR
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Now Published

(2-Fluoroallyl)pyridinium tetrafluoroborates: novel fluorinated electrophiles for Pd-catalyzed allylic substitution [opens in a new tab]
Angelina Yu. Bobrova, Maxim A. Novikov, Yury V. Tomilov journal article
Organic & Biomolecular Chemistry , Volume 19, Issue 21
Online publication date: 2021

Version History

Mar 24, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14268062.v1
D O I: 10.26434/chemrxiv.14268062.v1 [opens in a new tab]

Funding

Russian Science Foundation
19-73-00320
(Fluoroallyl)pyridinium tetrafluoroborates: a novel type of building blocks for palladium-catalyzed fluoroallylation in the synthesis fluoroalkene-based biologically active compounds and peptidomimetics
https://app.dimensions.ai/details/grant/grant.8659018 [opens in a new tab]

Author’s competing interest statement

No conflicts to declare

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