Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

(2-Fluoroallyl)pyridinium Tetrafluoroborates: Novel Fluorinated Electrophiles for Pd-Catalyzed Allylic Substitution

24 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient two-step approach to 2-fluoroallyl amines was developed that involves the synthesis of (2-fluoroallyl)pyridinium tetrafluoroborates from readily available gem-bromofluorocyclopropanes and the application of the former as novel and stable 2-fluoroallyl electrophiles for Pd-catalyzed allylic substitution

Keywords

fluoroalkenes
fluorocyclopropanes
palladium allylic substitution

Supplementary materials

Title
Description
Actions
Title
ESI - Experimental procedures
Description
Actions
Title
ESI-NMR
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

(2-Fluoroallyl)pyridinium tetrafluoroborates: novel fluorinated electrophiles for Pd-catalyzed allylic substitution [opens in a new tab]
Angelina Yu. Bobrova, Maxim A. Novikov, Yury V. Tomilov journal article
Organic & Biomolecular Chemistry , Volume 19, Issue 21
Online publication date: 2021

Version History

Mar 24, 2021 Version 1

Metrics

995
379
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14268062.v1
D O I: 10.26434/chemrxiv.14268062.v1 [opens in a new tab]

Funding

Russian Science Foundation
19-73-00320
(Fluoroallyl)pyridinium tetrafluoroborates: a novel type of building blocks for palladium-catalyzed fluoroallylation in the synthesis fluoroalkene-based biologically active compounds and peptidomimetics
https://app.dimensions.ai/details/grant/grant.8659018 [opens in a new tab]

Author’s competing interest statement

No conflicts to declare

Share