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Versatile and Ligand-Free Copper-Catalyzed α-Arylations of Aromatic Ketones Using Diaryliodonium Salts

17 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A ligand and base free copper catalyzed synthetic methodology for the efficient alpha-arylation of aromatic ketones has been developed. The reaction of the ketone-derived silyl enol ethers with diaryliodonium salts led to the intermolecular C-C coupling displaying high functional group tolerance with a low catalyst loading.

Keywords

copper ion
Catalysis

Supplementary materials

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Version History

Mar 17, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14222372.v1
D O I: 10.26434/chemrxiv.14222372.v1 [opens in a new tab]

Author’s competing interest statement

No conflict of interest

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