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Manganese Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen Borrowing Catalysis

16 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A phosphine ligand free manganese(I)-complex catalyzed the selective anti-Markovnikov hydroamination of allylic alcohols via waste-free hydrogen transfer mechanism. The γ-amino alcohol products are versatile synthetic intermediates for the synthesis of several drug molecules.

Keywords

Hydroamination
γ-amino alcohol
borrowing hydrogen catalysis
manganese
phosphine-free

Supplementary materials

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Version History

Mar 16, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14216921.v1
D O I: 10.26434/chemrxiv.14216921.v1 [opens in a new tab]

Funding

DST SERB (grant no. CRG/2019/001232)

Author’s competing interest statement

The authors declare no conflict of interest.

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