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The Interaction of Chondroitin Sulfate with a Lipid Monolayer Observed by Using Nonlinear Vibrational Spectroscopy

11 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We present the first vibrational sum-frequency generation spectroscopic study of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at the air-liquid interface. In the presence of Ca2+ and CS, the DPPC headgroups reoriented, while the tail orientations remained mostly unchanged. The results further suggest a chiral secondary structure for CS.

Keywords

phospholipid monolayer
chondroitin sulfate
vSFG
Vibrational Sum Frequency Spectroscopy
Air-liquid-interface

Supplementary materials

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Description
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Title
GPSZetal 20200310 SI
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Version History

Mar 11, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14192879.v1
D O I: 10.26434/chemrxiv.14192879.v1 [opens in a new tab]

Funding

DFG GSC 1013 SALSA
DFG 372486779
DFG 1340
DNFR107
CF20-0412
ERC 899687 (HS-SEQ)
German Academic Exchange Service (DAAD)

Author’s competing interest statement

No conflicts to declare

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