![Author ORCID: We display the ORCID iD icon alongside authors names on our website to acknowledge that the ORCiD has been authenticated when entered by the user. To view the users ORCiD record click the icon. [opens in a new tab]](https://chemrxiv.org/engage/assets/public/chemrxiv/images/logos/orcid.png)
Abstract
The property expansion of
three-dimensional (3D) functionalized covalent organic frameworks (COFs) is important
for developing their potential applications. Herein, we report the first case of 3D hydrazone-decorated
COFs as pH-triggered molecular switches,
and explore their application in the
stimuli-responsive drug delivery system. These functionalized
COFs with hydrazone groups on the channel walls were obtained via a
multi-component bottom-up synthesis strategy. They exhibit a reversible E/Z isomerization at various pH values,
confirmed by UV-vis absorption spectroscopy and proton conduction. Remarkably, after
loading cytarabine (Ara-C) as a model drug molecule, these pH-responsive COFs
showed an excellent and intelligent sustained-release effect with an almost 4-fold
increase in the Ara-C release at pH = 4.8 than at pH = 7.4,
which will effectively improve drug-targeting
and reduce drug side effects. Thus, these results open a way toward designing
3D stimuli-responsive functionalized COF materials and
promote their potential application as drug carriers
in the field of disease treatment.
Supplementary materials
Title
Figures-JUC556
Description
Actions
Title
SI-JUC556-20210303
Description
Actions
