Synthesis of Ferrocenesulfonyl Chloride, Key Intermediate Toward Ferrocenesulfonamides

Ferrocenesulfonyl chloride is the key intermediate in the synthesis of ferrocenesulfonamides, a family of underexplored derivatives. Here, we report a one-pot synthesis of this compound able to easily deliver multigram quantities of product. While we also described an original protocol for the synthesis of ferrocenesulfonamides, we highlighted the reactivity difference between arene and ferrocene sulfonyl chlorides. Finally, we described an example of diastereoselective deprotolithiation of chiral ferrocenesulfonamides.