Co-crystals of Praziquantel: Discovery by Network-Based Link Prediction

Jan-Joris Devogelaer; Maxime D. Charpentier; Arnoud Tijink; Valérie Dupray; Gérard Coquerel; Karen Johnston; Hugo Meekes; Paul Tinnemans; Elias Vlieg; Joop H. ter Horst; Rene de Gelder

doi:10.26434/chemrxiv.13562795.v1

Inorganic Chemistry

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Co-crystals of Praziquantel: Discovery by Network-Based Link Prediction

13 January 2021, Version 1

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Abstract

In this study, co-crystals for Praziquantel (PZQ), an anthelmintic drug used to treat schistosomiasis, are predicted with network-based link prediction. Single crystals of twelve co-crystal indications were grown and subjected to a structural analysis with single-crystal X-ray diffraction.

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