Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Nickel-Catalyzed Benzylic Alkynylation: Migratory Hydroalkynylation and Enantioselective Hydroalkynylation of Olefins with Bromoalkynes

02 February 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A nickel-hydride catalyzed reductive migratory hydroalkynylation of olefins with bromoalkynes that delivers the corresponding benzylic alkynylation products in high yield and with excellent regioselectivity has been developed. Catalytic enantioselective hydroalkynylation of styrenes has been realized using a simple chiral PyrOx ligand. The obtained enantioenriched benzylic alkynes are versatile synthetic intermediates and can be readily transformed into synthetically useful chiral synthons

Keywords

Asymmetric Catalysis
hydroalkynylation
Nickel Catalysis
Regioselectivity
alkenes
nickel hydride

Supplementary materials

Title
Description
Actions
Title
Jiang Asymmetric hydroalkynylation SI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Feb 02, 2021 Version 1

Metrics

1,666
527
1
Views
Downloads

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13681432.v1
D O I: 10.26434/chemrxiv.13681432.v1 [opens in a new tab]

Funding

National natural Science Foudation of China 21822105
National natural Science Foudation of China 21772087
National natural Science Foudation of Jiangsu Province (BK20190281, BK20201245)

Author’s competing interest statement

The authors declare no competing financial interest.

Share