Interrupted Aza-Wittig Reactions Using Iminophosphoranes to Synthesize 11C-Carbonyls

31 December 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Iminophosphoranes are reported as convenient precursors to amides, ureas, carbamates and other carbonyl-containing molecules through CO2-fixation. Key to this transformation with stable isotopes and carbon-11 is interception of the reactive isocyanate intermediate. Automated synthesis and isolation of PET radiopharmaceuticals is achieved.

Keywords

iminophosphorane
carbon dioxide (CO2)
carbon-11 (11C)
radiochemistry
Radiopharmaceuticals

Supplementary materials

Title
Description
Actions
Title
IAW-IMP ESI
Description
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