Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355

Bernhard Kepplinger; Joseph Cowell; Stephanie Morton-Laing; Corinne Wills; Emma Marrs; John Perry; Joe Grey; Michael Goodfellow; Jeff Errington; Michael Probert; Bill Clegg; Jonathan Bogaerts; Wouter Herrebout; Nick E. E. Allenby; Michael Hall

doi:10.26434/chemrxiv.13286078.v1

Organic Chemistry

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Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355

14 December 2020, Version 1

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Abstract

The application of genomic techniques to the investigation of understudied species of actinobacteria provides an expedited route to the discovery of new bioactive natural products. We report the isolation of the antibiotic polyketide tatiomicin, through a genomics and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355. Structural elucidation including absolute stereochemical assignment was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA).

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