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A Pathogen Mimetic Molecule Induces Highly Amplified Synergistic Immune Activation to Vaccination via Activation of Multiple Signaling Pathways

19 October 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We developed a small-molecule trimeric PRR agonist-based adjuvant inspired by the stimulation pattern of a pathogen. This molecule generated by covalently linking TLR2/6 agonist, NOD2 agonist, and NLRP3 inflammasome activator, stimulates multiple subfamilies of PRRs in a spatially defined manner resulting in an amplified innate immune response in vitro. Moreover, it elicits both stronger humoral and cellular immune responses in vivo.

Keywords

adjuvant • vaccines• pathogens • immunostimulants • antigen • pathogen associated molecular patterns • pattern recognition receptors

Supplementary materials

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chemrxiv manuscript
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Version History

Oct 19, 2020 Version 1

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License

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13105316.v1
D O I: 10.26434/chemrxiv.13105316.v1 [opens in a new tab]

Funding

NIH (5U01AI124286-05)

Author’s competing interest statement

No conflict of interest

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