An Overview of Coronaviruses: In-Silico Approach to Decipher Anti-SARS-CoV-2 Natural Products

In current study, we have focused on the outline of different coronaviruses including COVID-19, along with potential therapeutic targets of SARC-CoV-2. Moreover, experimentally evident anti-coronavirus natural molecules were subjected for in silico screening against M^pro and RdRp of COVID-19, in order to predict effective cure agent for same.Docking analysis have revealed hit molecules namely tetra-O-galloyl-β-D-glucose (2) and juglanin (25) against main protease, in reference of N3 molecule (docking score = -5.95 Kcal/mol), while glycyrrhizin (1) and tetra-O-galloyl-β-D-glucose (2) are good against RdRp in reference of Remdesivir (docking score = -4.23 Kcal/mol). In-silico parameter revealed three lead compounds i.e. glycyrrhizin (1), tetra-O-galloyl-β-D-glucose (2) and juglanin (25) which can be seen as hopeful molecule for COVID-19 treatment in upcoming time. Overall review lesson is to develop a specific and effective drug molecule against the current crisis i.e. COVID-19 derived from natural source.