In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

Shridhar Hiremath; Vinay Kumar H D; Nandan M; Mantesh M; Shankarappa K S; Venkataravanappa V; Jahir Basha C R; C N Lakshminarayana Reddy

doi:10.26434/chemrxiv.12751361.v1

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In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

05 August 2020, Version 1

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Abstract

No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR

Keywords

Andrographis paniculata

Phyllanthus amarus

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In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2

Shridhar Hiremath, H. D. Vinay Kumar, M. Nandan, M. Mantesh, K. S. Shankarappa, V. Venkataravanappa, C. R. Jahir Basha, C. N. Lakshminarayana Reddy journal article

3 Biotech , Volume 11, Issue 2

Online publication date: Jan 11, 2021

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Aug 05, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12751361.v1

Author’s competing interest statement

The authors declare that they have no competing interests

In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

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