Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Total Synthesis of Putative Structure of Asperipin-2a and Stereochemical Reassignment

04 August 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The total synthesis of the putative structure of asperipin-2a is described. The synthesis features ether cross-links between the phenolic oxygen of Tyr6 and β position of Tyr3 and the phenolic oxygen of Tyr3 and the β position of Hpp1 in the unique 17- and 14-membered bicyclic structure of asperipin-2a, respectively. The synthesized putative structure does not match the natural product and a stereochemical reassignment is postulated.

Keywords

Asperipin
Total Synthesis
peptide natural products

Supplementary materials

Title
Description
Actions
Title
Total synthesis of asperipin-2a SI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Aug 04, 2020 Version 1

Version Notes

Asperipin_ChemRxiv_V1

Metrics

3,594
642
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12756395.v1
D O I: 10.26434/chemrxiv.12756395.v1 [opens in a new tab]

Funding

Australian Research Council DP180101804

Author’s competing interest statement

no conflict of interest

Share