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Structure-Based Screening of Potential Triterpenoids for Anti-Viral Activity Against SARS-CoV-2 and Related Coronaviruses

03 August 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Triterpenoids possess valuable medicinal properties ranging from anti-microbial to anti-cancer. Some of them were known for their activity against HIV, Ebola and Influenza viruses. In this study, 108 triterpenoids were screened for its potential usage as anti-viral drug against SARS-CoV-2, MERS and SARS coronaviruses, using molecular docking calculation against their main proteases (Mpro) and ADME based drug-likeliness parameters.

Keywords

Main Protease, MPro
Triterpenoids
SARS-CoV -2
Docking Studies
Coronaviruses

Supplementary materials

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Version History

Aug 03, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12746558.v1
D O I: 10.26434/chemrxiv.12746558.v1 [opens in a new tab]

Author’s competing interest statement

There is no conflict of interest

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