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Ti-Catalyzed Ring-Opening Oxidative Amination of Methylenecyclopropanes with Diazenes

14 May 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The ring-opening oxidative amination of methylenecyclopropanes (MCPs) with diazenes catalyzed by py3TiCl2(NR) complexes is reported. This reaction selectively generates branched α-methylene imines as opposed to linear α,β-unsaturated imines, which are difficult to access via other methods

Keywords

titanium
methylenecyclopropane
catalysis
organometallics

Supplementary materials

Title
Description
Actions
Title
SI MCPs Chem Sci
Description
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Now Published

Ti-catalyzed ring-opening oxidative amination of methylenecyclopropanes with diazenes [opens in a new tab]
Evan P. Beaumier, Amy A. Ott, Xuelan Wen, Zachary W. Davis-Gilbert, T. Alexander Wheeler, Joseph J. Topczewski, Jason D. Goodpaster, Ian A. Tonks journal article
Chemical Science , Volume 11, Issue 27
Online publication date: 2020

Version History

May 14, 2020 Version 1

Version Notes

This is version 1.

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ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12284333.v1
D O I: 10.26434/chemrxiv.12284333.v1 [opens in a new tab]

Funding

National Institute of General Medical Sciences
R35GM119457
Ti-Catalyzed Nitrene Transfer Reactions
https://app.dimensions.ai/details/grant/grant.6377851 [opens in a new tab]
National Institute of General Medical Sciences
R35GM124718
Chiral α,α-Disubstituted Amine Synthesis by Dynamic Kinetic Resolution
https://app.dimensions.ai/details/grant/grant.7029425 [opens in a new tab]
Office of the Director
S10OD011952
Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical Research
https://app.dimensions.ai/details/grant/grant.2671476 [opens in a new tab]
Alfred P Sloan Foundation
DE-AC02-05CH11231

Author’s competing interest statement

No conflict of interest

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