Shotgun Drug Repurposing Biotechnology to Tackle Epidemics and Pandemics

William Mangione; Zackary Falls; Thomas Melendy; Gaurav Chopra; Ram Samudrala

doi:10.26434/chemrxiv.12045318.v1

Biological and Medicinal Chemistry

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Shotgun Drug Repurposing Biotechnology to Tackle Epidemics and Pandemics

31 March 2020, Version 1

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Abstract

In this manuscript we highlight consensus between the list of drugs currently in clinical trials to treat COVID-19, the worldwide pandemic caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), and the list of predictions made using our shotgun drug discovery, repurposing, and design platform known as CANDO (Computational Analysis of Novel Drug Opportunities). We make the argument that increased funding and development for drug repurposing biotechnology like ours will help combat the inevitable pathogenic outbreaks of the future.

Keywords

Computational drug discovery

Computational drug repositioning

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