Effect of Surface Structure on Peptide Adsorption on Soft Surfaces

David Cheung

doi:10.26434/chemrxiv.6723929.v1

Materials Science

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Effect of Surface Structure on Peptide Adsorption on Soft Surfaces

29 June 2018, Version 1

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Working Paper

David Cheung

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Using molecular dynamics simulations the adsorption of peptides onto nanostructured surfaces, consisting of alternating hydrophilic-hydrophobic stripes, was investigated. The adsorption strength, calculated using metadynamics, was found to decrease as the stripe width gets smaller. The contribution of peptide conformation, entropy, and water structure on the adsorption strengths were investigated.

Keywords

molecular dynamics

protein adsorption

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