In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2:  Inhibitor of RNA dependent RNA polymerase (RdRp) and Necessary Proteases

Trinath Chowdhury; Gourisankar Roymahapatra; Santi M Mandal

doi:10.26434/chemrxiv.12200495.v1

Biological and Medicinal Chemistry

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In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA dependent RNA polymerase (RdRp) and Necessary Proteases

28 April 2020, Version 1

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The work demonstrate screening of several arsenical compounds against RdRp of coronavirus. The study implies out of all arsenical compounds, darinaparsin shows its most effective results based on in silico docking analysis. This study also confirmed the significant interaction between the active site of viral replicase protein, endoribonuclease protein and different proteases with darinaparsin.

Keywords

COVID-19

Arsenical drug

Darinaparsin

RNA dependent RNA polymerase

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Apr 28, 2020 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12200495.v1

Author’s competing interest statement

There is no conflct of interest between the authors.