A Droplet Microfluidic Platform for High-Throughput Photochemical Reactions

Alexandra Sun; Daniel Steyer; Anthony Allen; Emory Payne; Robert Kennedy; Corey Stephenson

doi:10.26434/chemrxiv.12123978.v1

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A Droplet Microfluidic Platform for High-Throughput Photochemical Reactions

22 April 2020, Version 1

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the development of a droplet microfluidic/mass spectrometry platform for performing high-throughput photochemical reaction discovery on picomole scale. We also describe the successful translation of picomole scale flow screening conditions to millimole scale flow operations, highlighting the utility of this platform for discovery chemistry applications.

Keywords

photoredox catalysis

pharmaceutical synthesis

visible light

droplet microfluidics

mass spectrometry

high-throughput experimentation

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A droplet microfluidic platform for high-throughput photochemical reaction discovery

Alexandra C. Sun, Daniel J. Steyer, Anthony R. Allen, Emory M. Payne, Robert T. Kennedy, Corey R. J. Stephenson journal article

Nature Communications , Volume 11, Issue 1

Online publication date: Dec 03, 2020

Version History

Apr 22, 2020 Version 1

Version Notes

Updated version fixed grant acknowledgement

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12123978.v1

Funding

Directorate for Engineering

1604087

GOALI: Biocatalysis Development using High-throughput Droplet Microfluidics and Mass Spectrometry

https://app.dimensions.ai/details/grant/grant.5540515

Directorate for Mathematical & Physical Sciences

1900266

Redox catalysis strategies for synthesis

https://app.dimensions.ai/details/grant/grant.8452494

Author’s competing interest statement

none

A Droplet Microfluidic Platform for High-Throughput Photochemical Reactions

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