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A Molecular Logic Gate for the Naked-Eye Detection of Gluthatione or Pyrophosphate with a Nickel Based Bio-Sensor

21 April 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An inorganic water soluble Ni(II) complex offers a molecular logic gate for the naked-eye detection of pyrophosphate versus thiol derivatives. Pyrocathecol coordinated to nickel performs a thiol-michael addition click reaction in the presence of thiol derivativs whereas pyrophosphate allows a displacement of the indicator PCV leading to an indicator displacement assay.

Keywords

indicator displacement assay
nickel
gluthatione
pyrophosphate
pyrocathecol violet

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Version History

Apr 21, 2020 Version 1

Version Notes

version 1 (early working paper)

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12097824.v1
D O I: 10.26434/chemrxiv.12097824.v1 [opens in a new tab]

Funding

No fundings

Author’s competing interest statement

no conflict of interest

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