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A Dinuclear Copper Based Artificial Metalloenzyme for the Kinetic Resolution of Adrenalin

20 April 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Incorporation of a copper catalyst within carbonic anhydrase affords artificial metalloenzyme for the oxidation of catechols in aqueous solution at physiological pH. Optimization of the performance can be achieved either by chemical or genetic means. In addition, a model of enzyme/inhibitor is proposed and discussed.

Keywords

artificial metalloenzyme
copper
adrenaline
kinetic resolution

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Version History

Apr 20, 2020 Version 1

Version Notes

Paper version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.12143880.v1
D O I: 10.26434/chemrxiv.12143880.v1 [opens in a new tab]

Funding

no fundings

Author’s competing interest statement

No conflict of interest

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