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Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

17 January 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Keywords

innate immunity
adjuvant
glycolipid
lectin receptor
Mincle
glycoimmunology

Supplementary materials

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Now Published

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template [opens in a new tab]
Dylan G. M. Smith, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer J. Williams journal article
Chemical Communications , Volume 56, Issue 31
Online publication date: 2020

Version History

Jan 17, 2020 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.10567097.v1
D O I: 10.26434/chemrxiv.10567097.v1 [opens in a new tab]

Funding

Australian Research Council
DP160100597
Unravelling the immunology of complex glycolipids by chemical synthesis
https://app.dimensions.ai/details/grant/grant.5126834 [opens in a new tab]
Japan Agency for Medical Research and Development (AMED)

Author’s competing interest statement

no conflict of interest

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