Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

17 January 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Keywords

innate immunity
adjuvant
glycolipid
lectin receptor
Mincle
glycoimmunology

Supplementary materials

Title
Description
Actions
Title
draft 150120
Description
Actions
Title
supp info
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template [opens in a new tab]
Dylan G. M. Smith, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer J. Williams journal article
Chemical Communications , Volume 56, Issue 31
Online publication date: 2020

Version History

Jan 17, 2020 Version 1

Metrics

2,565
566
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.10567097.v1
D O I: 10.26434/chemrxiv.10567097.v1 [opens in a new tab]

Funding

Australian Research Council
DP160100597
Unravelling the immunology of complex glycolipids by chemical synthesis
https://app.dimensions.ai/details/grant/grant.5126834 [opens in a new tab]
Japan Agency for Medical Research and Development (AMED)

Author’s competing interest statement

no conflict of interest

Share