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A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

23 December 2019, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

Keywords

E3 Ligase
protein degradation
von Hippel Lindau
PROTAC
Caged ligand
Light Activated

Supplementary materials

Title
Description
Actions
Title
SI Kounde Caged PROTAC Chemrxiv 10 Dec 2019
Description
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Now Published

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light [opens in a new tab]
Cyrille S. Kounde, Maria M. Shchepinova, Charlie N. Saunders, Marcel Muelbaier, Mark D. Rackham, John D. Harling, Edward W. Tate journal article
Chemical Communications , Volume 56, Issue 41
Online publication date: 2020

Version History

Dec 23, 2019 Version 2

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11350079.v2
D O I: 10.26434/chemrxiv.11350079.v2 [opens in a new tab]

Funding

EP/R512540/1

Author’s competing interest statement

M.M. and J.D.H are employees and shareholders of GlaxoSmithKline (GSK). E.W.T. is a Director and shareholder of Myricx Pharma Ltd. M.D.R is an employee of Merck Sharp & Dohme.

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