Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization

Xiang Ji; Zheng Huang; Jean-Philip Lumb

doi:10.26434/chemrxiv.9999971.v1

Organic Chemistry

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Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization

24 October 2019, Version 1

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Abstract

Isoquinolines and their derivatives are present in many natural products and biologically active small molecules. Herein, we report a modified procedure for the Classical Pomeranz-Fritsch protocal, which expands the scope of 1,2-dihydroisoquinoline products.

Keywords

Isoquinoilne

Silyl Triflates

Lewis acid complexation

dihydroisoquinoline

tetrahydroisoquinoline compound

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Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz–Fritsch Cyclization

Xiang Ji, Zheng Huang, Jean-Philip Lumb journal article

The Journal of Organic Chemistry , Volume 85, Issue 2

Online publication date: Dec 19, 2019

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Oct 24, 2019 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.9999971.v1

Author’s competing interest statement

No Conflict of Interest

Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization

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