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A Dual Catalytic Platform for Enabling sp3 α C–H Arylation & Alkylation of Benzamides

23 October 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A dual catalytic sp3 a C–H arylation & alkylation of benzamides with organic halides is described. This protocol exhibits excellent chemoselectivity and exquisite site-selectivity, offering a complementary reactivity mode to existing sp3 arylation or alkylation events via either transition metal catalysis or photoredox events

Keywords

amides
arylation
alkylation
dual catalysis

Supplementary materials

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Now Published

Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides [opens in a new tab]
Alexander W. Rand, Hongfei Yin, Liang Xu, Jessica Giacoboni, Raul Martin-Montero, Ciro Romano, John Montgomery, Ruben Martin journal article
ACS Catalysis , Volume 10, Issue 8
Online publication date: Mar 27, 2020

Version History

Oct 23, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.10003277.v1
D O I: 10.26434/chemrxiv.10003277.v1 [opens in a new tab]

Funding

FEDER/MICIU –AEI/PGC2018-096839-B-100

Author’s competing interest statement

No conflict of interest

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