Absolute Autocatalytic Amplification Under Heterogenous Conditions Involving Subsequent Hydride Transfer and Hemiacetal Intermediate.

Giuesppe rotunno; Dirk Petersen; Mohamed Amedjkouh

doi:10.26434/chemrxiv.9619772.v1

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Absolute Autocatalytic Amplification Under Heterogenous Conditions Involving Subsequent Hydride Transfer and Hemiacetal Intermediate.

15 August 2019, Version 1

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Absolute asymmetric amplification is observed for pyridine alkanol by reaction with iPr₂Zn vapor under heterogenous conditions. Beside the chiral alkanol, formation of a chiral ester is observed and identified as a subsequent Claisen-Tishchenko product of a hemiacetal intermediate during a Soai absolute amplification.

Keywords

Asymmetric Catalysis

autocatalysis process

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Aug 15, 2019 Version 1

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DOI

10.26434/chemrxiv.9619772.v1

Author’s competing interest statement

No conflict of interest

Absolute Autocatalytic Amplification Under Heterogenous Conditions Involving Subsequent Hydride Transfer and Hemiacetal Intermediate.

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Author’s competing interest statement

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