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Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

15 August 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here we describe a new method for improving signalling potency and selectivity for suboptimal GPCR ligands through conjugation with receptor-targeting nanobodies

Keywords

Nanobody
Peptide
GPCR
Conjugation

Supplementary materials

Title
Description
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Title
SUPPORTING INFORMATION 08052019
Description
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Version History

Aug 15, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.9619823.v1
D O I: 10.26434/chemrxiv.9619823.v1 [opens in a new tab]

Author’s competing interest statement

HLP, RWC and TJG have filed a provisional patent covering this work

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