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A Metal-Free Facile Construction of C(sp3) –CF3 Bond: Trifluoromethylation of Hydrazones with Togni’s Reagent under Mild Conditions

18 June 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A metal-free trifluoromethylation of hydrazones with Togni’s reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen and heterocyclic compounds were tolerated. This simple and green strategy provides a practical tool to construct C(sp3) –CF3 bonds

Keywords

C(sp3)-CF3 bond formation
Hydrazones
Metal-free

Supplementary materials

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Supporting Information 0615
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Version History

Jun 18, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.8282258.v1
D O I: 10.26434/chemrxiv.8282258.v1 [opens in a new tab]

Author’s competing interest statement

There are no conflicts to declare.

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