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Abstract
We describe a method to protect the sensitive stereochemistry of the thioamide—in analogy to the protection of the functional groups of amino acid side chains—in order to preserve the thioamide moiety during peptide elongation.
A Strategy for Thioamide Incorporation During Fmoc Solid-Phase Peptide Synthesis with Robust Stereochemical Integrity
31 May 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.
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Version History
May 31, 2019 Version 1
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Author’s competing interest statement
The authors declare no conflicts of interest