Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

04 April 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.

Keywords

Podophyllotoxin
Total synthesis
Biocatalysis

Supplementary materials

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ODD SI 040319 FINAL
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