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Anti-proliferative Activity of N-Heterocyclic Carbenes Derived from Guanosine

26 March 2018, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbene derived from Guanosine are synthesized via oxidative addition. Cytotoxicity of the compounds is evaluated with human embryonic kidney (HEK293) cells, glioblastoma (U251) cervical cancer (HeLa) cells and prostate cancer (PC3) cells. Compounds 2a, 2b and 3a are highly selective for glioblastoma.

Keywords

N-heterocyclic carbenes
nucleosides
guanine
anticancer
platinum compounds

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Now Published

N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity [opens in a new tab]
Maria Inês P. S. Leitão, Federico Herrera, Ana Petronilho journal article
ACS Omega , Volume 3, Issue 11
Online publication date: Nov 16, 2018

Version History

Mar 26, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.6022919.v1
D O I: 10.26434/chemrxiv.6022919.v1 [opens in a new tab]

Author’s competing interest statement

No conflict of interest

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