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Small-Molecule (Micro)arrays for Sensitive Multiplex Metabolites Detection by Surface Plasmon Resonance Imaging

01 March 2018, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Small-molecule (micro)arrays were developed to measure three metabolites simultaneously by surface plasmon resonance imaging for the first time. To tackle the low sensitivity challenge associated with small molecule detection, antibodies were employed as the signal amplifiers. This work demonstrates both inhibition and displacement formats are applicable for sensitive multiplex metabolites detection.

Keywords

surface plasmon resonance imaging
multiplex assay
small-molecule metabolites
small-molecule microarrays

Supplementary materials

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AC4 ESI ChemRxiv
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Version History

Mar 01, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.5930644.v1
D O I: 10.26434/chemrxiv.5930644.v1 [opens in a new tab]

Funding

Alberta Innovate Health Solutions and Natural Sciences and Engineering Research Council of Canada

Author’s competing interest statement

No conflict of interest.

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