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Buchwald-Hartwig Amination Using Pd(I) Dimer Precatalysts Supported by Biaryl Phosphine Ligands

05 January 2018, Version 1

Abstract

We report the synthesis of air-stable Pd(I) dimer complexes featuring biaryl phosphine ligands. Catalytic experiments suggest that these complexes are comptent precatalysts that can mediate cross-coupling amination reactions between aryl halide electrophiles with both aliphatic and aromatic amine nucleophiles. This work represents an expansion of the air-stable precatalyst toolbox for Pd-catalyzed cross-coupling transformations.

Keywords

buchwald-hartwig amination
palladium
catalysis
Pd(I) dimer
cross-coupling
phosphine ligand
Chemistry

Supplementary materials

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kirlikovali et al SI
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Now Published

Buchwald–Hartwig amination using Pd(i) dimer precatalysts supported by biaryl phosphine ligands [opens in a new tab]
Kent O. Kirlikovali, Eunho Cho, Tyler J. Downard, Lilit Grigoryan, Zheng Han, Sooji Hong, Dahee Jung, Jason C. Quintana, Vanessa Reynoso, Sooihk Ro, Yi Shen, Kevin Swartz, Elizabeth Ter Sahakyan, Alex I. Wixtrom, Brandon Yoshida, Arnold L. Rheingold, Alexander M. Spokoyny journal article
Dalton Transactions , Volume 47, Issue 11
Online publication date: 2018

Version History

Jan 05, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.5758551.v1
D O I: 10.26434/chemrxiv.5758551.v1 [opens in a new tab]

Funding

UCLA

Author’s competing interest statement

This work was completed as a part of an advanced inorganic/organometallic chemistry undergraduate laboratory course (Chemistry 174) taught at UCLA during the Winter of 2017 by A. M. Spokoyny. Kent O. Kirlikovali, Dahee Jung and Alex Wixtrom were teaching assistants in the course. Eunho Cho, Tyler J. Downward, Lilit Grigoryan, Zheng Han, Sooji Hong, Jason C. Quintana, Vanessa Reynoso, Sooihk Ro, Yi Shen, Kevin Swartz, Elizabeth Ter Sahakyan and Brandon Yoshida were undergraduate students enrolled in the course.

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