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Functional Switching of a Native Neuropeptide Through Interactions with Pathogenic Factors in Dementia

07 June 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We discovered that the function of a native neuropeptide, somatostatin (SST), is switched through its conformational transition in the presence of metal ions, metal-free amyloid-beta (Abeta), and metal-bound Abeta that are associated with toxicity observed in the brains of Alzheimer’s disease patients.

Keywords

Somatostatin
amyloid beta peptides
metal ions
Alzheimer's disease

Supplementary materials

Title
Description
Actions
Title
SST SI MHL
Description
Actions

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Version History

Jun 07, 2021 Version 1

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License

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14736882.v1
D O I: 10.26434/chemrxiv.14736882.v1 [opens in a new tab]

Funding

National Research Foundation of Korea (NRF)
KAIST Advanced Institute for Science-X (KAIX)

Author’s competing interest statement

The authors declare no competing financial interests.

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